DAY 1ResonanceLocation: Carnegie Hall | Date: December 24, 1997
Aya Brea, an NYPD rookie attending an opera at Carnegie Hall, watches the lead actress Melissa Pearce cause the audience to burst into flames. Aya is immune and confronts Melissa on stage, discovering her Parasite Energy powers. Melissa mutates into Eve and descends into the sewers.
1
Enter Carnegie Hall and watch the opera cutscene. The audience combusts — only Aya and Melissa survive.
2
Confront Melissa on stage. This is the first boss fight where Aya learns she can use Parasite Energy. Melissa attacks with targeted energy beams.
TIP: Fight clean. Bonus Points are earned per battle and taking damage reduces the award. Spend them on ATB speed, item capacity, or weapon and armor attributes; anything unspent carries into the next round.
3
After Melissa levitates away, head downstairs. Aya witnesses a rat mutate into an NMC (Neo-Mitochondrial Creature).
4
Find the diary backstage revealing Melissa overdosed on immunosuppressants after her kidney transplant, fearing she'd lose her lead role.
TIP: The Rehearse Key comes out of Melissa's diary. The Theater Key is on a burned body in the dressing rooms.
5
Confront Melissa in the Rehearsal Room, where she plays the piano. She mutates into Mitochondria Eve and escapes into the sewers.
6
Navigate the sewers, fighting mutant frogs and an alligator boss. Find your way back outside.
WARNING: The police cordon off Carnegie Hall the moment Day 1 ends and it never returns to the map. Sweep it before you leave: the M1911A1 is tucked in shadow near the sewer stairs, and there are chests behind the pillars and partitions.
7
Aya's partner Daniel Dollis escorts her away. She learns she is the sole survivor.
Key Items
Theater Key
Dressing Room Key — found in Carnegie Hall backstage area.
Rehearse Key
Rehearsal Room Key — found in Carnegie Hall.
N Protector
Normal armor (DE 11+1, PE 9, CR 16+2, 3 slots). Carnegie Hall, long hallway — first room on the left through a crawlspace. MISSABLE
P220
Pistol (ATK 14+1, Range 55, 5 bullets, 1 slot). Carnegie Hall basement. MISSABLE
M1911A1
Pistol (ATK 15+2, Range 60, 5+1 bullets, 2 slots). Carnegie Hall sewers. MISSABLE
Kv Vest 1
Kevlar armor (DE 19+1, PE 11+1, CR 15, 2 slots). Dropped by Alligator boss in sewers.
Bosses
BOSS Melissa (Stage)
Melissa attacks with targeted energy beams. Move constantly to dodge. Use Aya's default M84F pistol and attack when your ATB is full. This is a tutorial fight where you learn Parasite Energy — Aya's Heal 1 ability is available from the start.
BOSS Eve (Rehearsal Room)
Eve is more aggressive with energy attacks. Keep moving and attack with your best pistol between her attacks. Use Heal 1 (60 PE) to recover 30 HP when needed. She will eventually flee.
BOSS Alligator
A giant mutated alligator in the sewers. It has powerful melee attacks. Keep your distance, use the M1911A1 if available (higher rate of fire), and circle around it. It drops the Kv Vest 1 armor.
DAY 2FusionLocations: NYPD, Central Park | Date: December 25, 1997 (Christmas)
The police attempt to suppress Eve's existence. At a press conference, Captain Baker covers up the Carnegie Hall incident, but Aya reveals the truth. Aya and Daniel visit Dr. Klamp at the museum, then pursue Eve to Central Park where she turns the audience at Delacorte Theater into an orange slime mass.
1
Attend the press conference at NYPD. Aya reveals the truth about Eve despite Baker's objections.
2
Collect both Mod Permits from Baker at the NYPD. These are critical — use both with Torres before Day 3, because he dies on Day 3.
TIP: Each Mod Permit adds one slot to a weapon or armor when you hand it to Torres. These are the only two in the Normal Game.
3
Visit Dr. Hans Klamp at the American Museum of Natural History. He explains mitochondria and Mitochondrial Eve. When Aya mentions 'Eve,' Klamp becomes surprised and stops talking.
4
Pursue Eve to Central Park. Daniel stays outside due to the danger of combustion.
5
Explore Central Park. Find the Zoo Key and various equipment in the office and forest areas.
WARNING: Central Park and the zoo are a one-visit area. Once the confrontation at the amphitheatre ends the day, the area closes, so empty the office and the forest first. The Zoo Key is in a drawer in the zoo office.
TIP: The birds in the park drop Junk in packs. Every 300 Junk you give Wayne buys one special weapon, so start banking it now.
6
Reach the Delacorte Theater. Eve turns the audience into an orange slimy mass. Battle Eve during an immolated horse ride. Aya is knocked unconscious.
7
Daniel discovers his son Ben escaped being turned to slime, but his ex-wife Lorraine was not so fortunate. Manhattan is evacuated. Maeda finds Aya and takes her to a vacated apartment.
Key Items
Mod Permit 1
Permit from Baker at NYPD. Use with Torres to add weapon slots. MISSABLE KEY ITEM
Mod Permit 2
Second permit from Baker at NYPD. MISSABLE KEY ITEM
Cm Vest 1
Chemical armor (DE 15+1, PE 16, CR 10+1, 2 slots). Uses Medicine when HP is low. NYPD locker room.
M16A1
Rifle (ATK 34+1, Range 110+2, 15+1 bullets, 1 slot). Given by Torres on Day 2.
M9
Pistol (ATK 17, Range 53+1, 8+1 bullets, 3 slots). Central Park, box near entrance (may be P8 instead).
Zoo Key
Central Park Key. KEY ITEM
Sp Vest 1
Spectra armor (DE 20+2, PE 14+1, CR 18+1, 2 slots). Central Park office.
Sv Vest 1
Survival armor (DE 18+1, PE 14+2, CR 19, 2 slots). Increases item capacity by 1. Central Park forest.
M203
Grenade launcher (ATK 25+2, Range 59+1, 5 bullets, 2 slots). Adds Heat effect. Central Park.
MP5K
Machine gun (ATK 35+1, Range 43, 23+1 bullets, 1 slot). NYPD Weapons Storage. Requires Storage Key (Day 3).
Bosses
BOSS Giant Worms
Large worm-like NMCs in Central Park. They emerge from the ground and attack with body slams. Use rifles or machine guns for rapid fire. Keep moving to avoid being surrounded.
BOSS Eve (Horse Ride)
Eve rides an immolated horse at the Delacorte Theater. She attacks with energy projectiles while moving. Time your attacks between her barrages. The fight ends when Aya is knocked unconscious — you don't need to defeat her here.
DAY 3SelectionLocations: Soho, NYPD | Date: December 26, 1997
Aya awakens in a Soho apartment with Daniel and Maeda. Maeda reveals Eve's origins — a scientist's wife's mitochondria took over her body. Maeda believes Eve is trying to give birth to an 'Ultimate Being.' The three visit Klamp again, then rush to the police station which has been attacked by Eve.
1
Wake up in the Soho apartment. Maeda explains the origins of Eve and the Ultimate Being theory.
2
Visit the Soho gun store for weapons and armor. Find Trading Card 1 in a garbage can near the Soho apartment.
WARNING: Soho is a one-visit area. Empty both the gun store and the pharmacy, and take the Trading Card from the rubbish outside. Speak to Cathy, Warner and Wayne before you leave, because the day ends on a forced fight.
3
Visit Dr. Klamp again. He tells Aya that the nuclei in her cells are fighting Eve's mitochondria. He asks questions then dismisses them.
4
Return to the NYPD precinct, which has been attacked by Eve. Save Ben and Baker from the mutated police dog Sheeva. Later, a Dogman kills Torres Owens in the Weapons Department.
5
Search the NYPD ground-floor changing room locker. Find Trading Card 2.
6
Pick up the M92F pistol from Wayne at the NYPD.
TIP: Wayne also trades Junk for weapons. At 300 Junk he builds one top-tier weapon of the class you name, the earliest being Day 4. Ask for a type (Pistol DE50AE7, Rifle MAG, Machine Gun P90, Shotgun M10B, Grenade Launcher HK40, Rocket Launcher LAW80) and never let him choose — that rolls a lesser weapon or wastes the 300 Junk. Your total is cumulative, so 600 buys a second weapon.
Key Items
Trading Card 1
Normal Trading Card. In a garbage can near the Soho apartment. Give to Wayne for weapon mods. MISSABLE
Trading Card 2
Normal Trading Card. In a locker in the NYPD ground-floor changing room. Give to Wayne for weapon mods. MISSABLE
M11
Machine gun (ATK 32+1, Range 42, 20+1 bullets, 2 slots). Soho gun store.
G19
Pistol (ATK 30+2, Range 57+1, 8+2 bullets, 3 slots). Soho gun store.
Cr Vest 1
Ceramics armor (DE 27+2, PE 24, CR 29+1, 2 slots). Soho.
Hamaya
Special good luck charm. Found in the Soho area. KEY ITEM
Cm Vest 2
Chemical armor (DE 30+1, PE 33+2, CR 21+2, 2 slots). NYPD conference room.
M92F
Pistol (ATK 28+1, Range 50+1, 8+3 bullets, 3 slots). Given by Wayne on Day 3.
Storage Key
NYPD Weapons Storage Key. Allows access to MP5K. KEY ITEM
Locker Key
NYPD Locker Key. KEY ITEM
MP5K
Machine gun (ATK 35+1, Range 43, 23+1 bullets, 1 slot). NYPD Weapons Storage (use Storage Key).
SG550
Rifle (ATK 40, Range 108+2, 20+1 bullets, 2 slots). Dropped by Giant Dogman boss.
N Jacket
Normal armor (DE 34+1, PE 28+1, CR 19, 3 slots). NYPD 3rd floor.
M9-2
Pistol (ATK 38+1, Range 54+1, 10+1 bullets, 2 slots). Dropped by Sheeva (Kerberos) boss.
Bosses
BOSS Sheeva / Kerberos (Mutated Police Dog)
A mutated police dog with a barrier that makes it difficult to damage. Use offense boosters and items to break through its defenses. Physical attacks alone won't suffice — use Parasite Energy (Energy Shot once you reach Lv15) and offensive items. It drops the M9-2 pistol. A Dogman later kills Torres Owens in the Weapons Department.
DAY 4ConceptionLocation: St. Francis Hospital | Date: December 27, 1997
Aya and Maeda head to St. Francis Hospital, where Maeda believes Eve will try to obtain sperm for the Ultimate Being. The hospital is overrun with NMCs. Eve has already taken the sperm. Aya discovers her mother's and sister's medical records.
1
Enter St. Francis Hospital, overrun with NMCs. Try to save remaining staff and patients.
WARNING: The hospital is a one-visit area. A hidden box behind the overturned cabinet can be searched repeatedly for Trading Cards, but only while you are in that room the first time. Empty your inventory before you open it, because leaving the room closes it for good.
2
Explore the basement. Eve traps Aya by cutting off power to the elevator.
3
Find Fuse 1 on top of the bookcases in the library room, Fuse 2 on a medicine box in the autopsy area and Fuse 3 in the bottom-right corner of the dark room. Insert them in the fuse box, reconnect the wires and switch the power on.
TIP: At the reservoir pumps, set Master Power ON, run Pump 1, run Pump 2, then set Master Power OFF and head north (the order of the two pumps does not matter). This drains the reservoir and lets the Giant Slime out. The Slime respawns every time you re-enter its room and a Club-type weapon can steal Defense +1 from it, so it is the best place to farm.
4
Explore the upper floors. Discover Aya's mother's and sister's medical records.
TIP: Past the green keycard doors, turn the wheels on the pipes in the bottom right to cut the liquid nitrogen feed to the sperm bank.
5
Reach the rooftop. Eve telepathically kills fighter jet pilots. She has already taken the sperm and flees.
6
Defeat the Spiderwoman boss on the rooftop.
7
Aya jumps off the roof before it is struck by the crashing jets. Reunite with Daniel and Maeda.
Key Items
Mayoke
Helpful good luck charm. Found in the hospital. KEY ITEM
Fuse 1
Fuse for restoring elevator power. Hospital basement. KEY ITEM
Fuse 2
Fuse for restoring elevator power. Hospital basement. KEY ITEM
Fuse 3
Fuse for restoring elevator power. Hospital basement. KEY ITEM
M79
Grenade launcher (ATK 44+1, Range 65+2, 4+1 bullets, 3 slots). Adds Tranquilizer. Hospital basement.
Autopsy Key
St. Francis Hospital key. KEY ITEM
Blue Cardkey
Blue magnetic cardkey for hospital access. KEY ITEM
Green Cardkey
Green magnetic cardkey for hospital access. KEY ITEM
M10
Machine gun (ATK 37+1, Range 45, 22+2 bullets, 2 slots). Hospital basement (may be Micro UZ instead).
Super Tool
Moves equipped parameter or effect without destroying the source weapon. Hospital. VALUABLE
Sp Jacket
Spectra armor (DE 35, PE 29+1, CR 26, 2 slots). Hospital 1st floor.
G3A3
Rifle (ATK 43+1, Range 121+2, 18+1 bullets, 3 slots). Hospital 13th floor.
Elevator Key
Elevator key for hospital. KEY ITEM
B Vest 1
Bio armor (DE 29+1, PE 35, CR 20, 2 slots). Resist Poison. Hospital 1st floor.
Puzzle
Restore Elevator Power
Eve cuts off power to the hospital elevator, trapping Aya in the basement. Find all 3 fuses (Fuse 1, Fuse 2, Fuse 3) scattered in the basement area. Insert them into the fuse box to restore elevator power and continue exploring the upper floors.
Bosses
BOSS Spiderwoman (Rooftop)
A giant spider-like NMC on the hospital rooftop. It attacks with web projectiles that can immobilize Aya. Dodge the web attacks by moving constantly — strafe left and right. Use your best rifle or machine gun for sustained fire. The G3A3 (found on the 13th floor) is excellent here. Watch out for its lunging attack when you get too close.
DAY 5EvolutionLocations: Sewers, Chinatown, Subway, Warehouse, Museum, Liberty Island | Date: December 28, 1997
Day 5 is the longest day, spanning three areas. Aya investigates the sewers, a warehouse, and the Museum of Natural History. She discovers Klamp engineered sperm for Eve, fights reanimated dinosaurs, and confronts a pregnant Eve at Liberty Island.
Part 1: Sewers
1
Enter the sewers following evidence of mutant slime in the water supply.
TIP: Maeda hands you a charm on the surface before you go down. The sewers use the same pump mechanic as the hospital, plus a ladder-and-drain route through to the subway tracks. The frogs here drop Junk.
2
Use the control panel to pump orange slime away from the city's water reservoir, preventing contamination.
3
Navigate the sewer labyrinth, collecting the Pump Key, Warehouse Key, and Gate Key. Fight the Centipede boss in the Subway.
4
Find the Cr Protector armor in the sewer labyrinth (easy to miss).
Pump Key
Pumping station key. Sewers. KEY ITEM
Warehouse Key
Port storage key. Sewers. KEY ITEM
Gate Key
Subway gate key. Sewers. KEY ITEM
M203-2
Grenade launcher (ATK 48+1, Range 65, 6+1 bullets, 2 slots). Adds Heat effect. Warehouse.
M870
Shotgun (ATK 48+1, Range 60, 4+3 bullets, 6 slots). Burst: Spray Multiple Targets. Chinatown sewer.
Cr Protector
Ceramics armor (DE 39+2, PE 41+2, CR 25+1, 2 slots). Increases Max HP; AT recharges slower. Chinatown sewer labyrinth. MISSABLE
Pump Orange Slime from Water Supply
The orange mass of people from Central Park has entered the city water supply. Use the control panel in the sewer pumping station to pump the slime away, preventing it from infecting the city's water reservoir. This is a critical story puzzle.
Part 2: Warehouse
5
Enter the Pier No. 3 warehouse using the Warehouse Key from the sewers. Fight the Crab boss in the warehouse basement.
WARNING: The warehouse is optional and open on Day 5 only. Skip it and you lose the AT4 rocket launcher, the PPK, an M203-2, several armor pieces and a Defense +2 for that run. The Tool in the north-west corner sits behind venting steam — grab it in the gap when the steam draws back into the pipe.
6
Collect armor and equipment, including the Sp Protector and Cm Protector.
B Protector
Bio armor (DE 32+1, PE 38, CR 22+1, 2 slots). Resist Stiffness. Subway.
M79-2
Grenade launcher (ATK 45+1, Range 68, 4+2 bullets, 4 slots). Adds Acid effect. Subway Station.
B Vest 1 (Warehouse)
May be found in warehouse area.
Sp Protector
Spectra armor (DE 38+1, PE 23, CR 26, 3 slots). Warehouse.
Cm Protector
Chemical armor (DE 36+1, PE 48, CR 29+2, 3 slots). Uses Medicine when HP is low. Warehouse.
Mayoke
Helpful good luck charm. Found during Day 5. KEY ITEM
Part 3: Museum of Natural History
7
Visit Dr. Klamp at the museum. Discover he has engineered special sperm for Eve to create the Ultimate Being. Aya tries to arrest him but he bursts into flames and dies after Daniel shoves him.
8
Fight the reanimated dinosaurs in the museum exhibits, including the Triceratops on the 3rd floor and the Tyrannosaur on the 1st floor.
TIP: Answer every interactive exhibit pedestal in the museum; each correct answer dispenses an item (medicines, ammo or a Revive). The answers: 9 animals in the picture; Mitochondria appeared inside the first organism; it fed on nitrogen oxides produced by volcanoes; ATP is about 200,000 volts per cubic centimetre; taking mitochondria in led to ageing; Mitochondria Eve is an African female; oxygen rose 25 million years ago because of photosynthesis by bacteria. The museum lizards drop Junk.
9
Find a pregnant Eve in another part of the museum. The slime mass forms a giant monster that carries Eve away in its protective shield. Do not take the hidden elevator in the Museum security office up to Eve's chamber on the 4th floor until you are done with the Chrysler Building in an EX Game; it locks the city and the Chrysler Building for that playthrough.
POINT OF NO RETURN: The hidden elevator is in the security office — walk off the right edge of the screen to find it. Taking it up to Eve ends Manhattan permanently: no city map, no shops, no police storage, and no Chrysler Building for the rest of that playthrough. In an EX Game this is where you forfeit the true ending, so finish every Chrysler run and storage trip first. The 4th-floor room holds the M500 and the B Jacket 1.
10
The military asks Aya to attack Eve from a helicopter (she's the only one who can approach without combusting). Attack from the chopper, then finish the fight on Liberty Island beside the wrecked Statue of Liberty.
MP5PDW
Machine gun (ATK 52+1, Range 46, 23+2 bullets, 2 slots). Museum 2nd floor.
Cr Vest 2
Ceramics armor (DE 45+1, PE 42+1, CR 31, 2 slots). Museum 2nd floor.
M203-4
Grenade launcher (ATK 57+1, Range 67, 7+1 bullets, 5 slots). Adds Frost effect. Museum 1st floor.
M500
Shotgun (ATK 57+2, Range 61+2, 5+2 bullets, 8 slots). Burst: Spray. Museum 4th floor.
N Suit
Normal armor (DE 43+1, PE 35+1, CR 22+1, 2 slots). Museum 1st floor.
Sv Protector
Survival armor (DE 38+1, PE 35+1, CR 30, 2 slots). Increases item capacity by 1. Museum 3rd floor.
B Jacket 1
Bio armor (DE 43+1, PE 48+1, CR 27+1, 3 slots). Resist Poison. Museum 4th floor, security room (right of control panels, secret elevator).
Bosses
BOSS Slime Monster
The orange slime mass from Central Park has become a giant monster. It surrounds Eve in a protective shield. You fight it from a helicopter first — use your best weapons to damage it. It has multiple attack patterns including sweeping slams and projectile slime.
BOSS Eve (Liberty Island)
The final confrontation with Eve beside the wrecked Statue of Liberty. Eve has multiple phases. Attack from the helicopter first, then fight her personally on the ground. She uses powerful energy attacks — use Barrier (if unlocked at Lv13) and Haste (Lv20) to survive. Use Energy Shot or Liberate for burst damage. Eve finally succumbs and dies.
DAY 6LiberationLocation: Naval Vessel | Date: December 29, 1997
Aya rests on a naval vessel. Maeda and Daniel are relieved she is safe. However, the Ultimate Being is born and attacks the surrounding ships. Aya must defeat it and escape before the ship explodes.
1
Before you leave for the docks, have Wayne engrave Aya's name on one weapon and one armor and put anything worth keeping into police storage. This is the last chance. Rest on the naval vessel. Receive Maeda's Gun and DNA Bullets — the only weapons that can damage the Ultimate Being.
WARNING: The engraved weapon and armor, everything in police storage, your Bonus Points and your running Junk total carry into the EX Game; Aya's level resets to 1 and plot items (keys and Maeda's charms) are stripped. Without an engraved pair you start the EX Game with nothing. If you already carry engraved gear from an earlier run and engrave new items, the old pair is lost when the EX Game starts — park the old customs in police storage first.
2
The Ultimate Being is born and attacks. Battle it across multiple forms as it evolves during the fight.
3
Set the vessel's boiler pressure dangerously high to destroy the ship with the Ultimate Being onboard.
4
Escape the ship before it explodes. Aya jumps off and the cruiser explodes, killing the Ultimate Being.
TIP: Let the credits run all the way out and save the clear data. That grants 3,000 Bonus Points and puts EX GAME above New Game on the title screen.
Key Items
Maeda's Gun
Pistol (ATK 1, Range 60, 15 bullets, 1 slot). Given by Maeda on Day 6. Cannot be removed from inventory. Required to damage the Ultimate Being. KEY ITEM
DNA Bullets
Maeda's special bullets for Maeda's Gun. Given near endgame. Required to damage the Ultimate Being. KEY ITEM
Bosses
BOSS Ultimate Being (4 Forms)
The Ultimate Being evolves through multiple forms during the fight, fusing with objects on the vessel. You MUST use Maeda's Gun with DNA Bullets — normal weapons cannot damage it. The being's mitochondria cause it to evolve at an alarming rate. Each form is stronger than the last. Use Liberate (if at Lv33) for massive burst damage. After weakening it, set the boiler pressure high and escape before the ship explodes. The cruiser explodes, killing the Ultimate Being.
TIP: After the credits roll, the EX Game (New Game+) unlocks, granting access to the Chrysler Building and the true final boss.