Complete Story Walkthrough (Day-by-Day)
This walkthrough covers all 6 days of Parasite Eve, with key items, boss strategies, and missable warnings for each day.
Day 1: Resonance
Location: Carnegie Hall | Date: December 24, 1997
Aya Brea, an NYPD rookie attending an opera at Carnegie Hall, witnesses the lead actress Melissa Pearce spontaneously combust the audience. Aya is immune and confronts Melissa on stage, discovering her Parasite Energy powers. Melissa mutates into Eve and descends into the sewers.
1
Enter Carnegie Hall and watch the opera cutscene. The audience combusts — only Aya and Melissa survive.
2
Confront Melissa on stage. This is the first boss fight where Aya learns she can use Parasite Energy. Melissa attacks with targeted energy beams.
3
After Melissa levitates away, head downstairs. Aya witnesses a rat mutate into an NMC (Neo-Mitochondrial Creature).
4
Find the diary backstage revealing Melissa overdosed on immunosuppressants after her kidney transplant, fearing she'd lose her lead role.
5
Confront Melissa backstage (playing the piano). She mutates into Mitochondria Eve and descends into the sewers.
6
Navigate the sewers, fighting mutant frogs and an alligator boss. Find your way back outside.
7
Aya's partner Daniel Dollis escorts her away. She learns she is the sole survivor.
Key Items
Theater Key
Dressing Room Key — found in Carnegie Hall backstage area.
Rehearse Key
Rehearsal Room Key — found in Carnegie Hall.
N Protector
Normal armor (DE 11+1, PE 9, CR 16+2, 3 slots). Carnegie Hall, long hallway — first room on the left through a crawlspace. MISSABLE
P220
Pistol (ATK 14+1, Range 55, 5 bullets, 1 slot). Carnegie Hall basement. MISSABLE
M1911A1
Pistol (ATK 15+2, Range 60, 5+1 bullets, 2 slots). Carnegie Hall sewers. MISSABLE
Kv Vest 1
Kevlar armor (DE 19+1, PE 11+1, CR 15, 2 slots). Dropped by Alligator boss in sewers.
Bosses
BOSS Melissa (Stage)
Melissa attacks with targeted energy beams. Move constantly to dodge. Use Aya's default M84F pistol and attack when your ATB is full. This is a tutorial fight where you learn Parasite Energy — Aya's Heal 1 ability unlocks here.
BOSS Eve (Sewers)
Eve is more aggressive with energy attacks. Keep moving and attack with your best pistol between her attacks. Use Heal 1 (60 PE) to recover 30 HP when needed. She will eventually flee.
BOSS Alligator
A giant mutated alligator in the sewers. It has powerful melee attacks. Keep your distance, use the M1911A1 if available (higher rate of fire), and circle around it. It drops the Kv Vest 1 armor.
Day 2: Fusion
Locations: NYPD, Central Park | Date: December 25, 1997 (Christmas)
The police attempt to suppress Eve's existence. At a press conference, Captain Baker covers up the Carnegie Hall incident, but Aya reveals the truth. Aya and Daniel visit Dr. Klamp at the museum, then pursue Eve to Central Park where she turns the audience at Delacorte Theater into an orange slime mass.
1
Attend the press conference at NYPD. Aya reveals the truth about Eve despite Baker's objections.
2
Collect Mod Permits from Baker. These are critical — use them with Torres to add weapon modification slots.
3
Visit Dr. Hans Klamp at the American Museum of Natural History. He explains mitochondria and Mitochondrial Eve. When Aya mentions 'Eve,' Klamp becomes surprised and stops talking.
4
Pursue Eve to Central Park. Daniel stays outside due to the danger of combustion.
5
Explore Central Park. Find the Zoo Key and various equipment in the office and forest areas.
6
Reach the Delacorte Theater. Eve turns the audience into an orange slimy mass. Battle Eve during an immolated horse ride. Aya is knocked unconscious.
7
Daniel discovers his son Ben escaped being turned to slime, but his ex-wife Lorraine was not so fortunate. Manhattan is evacuated. Maeda finds Aya and takes her to a vacated apartment.
Key Items
Mod Permit 1
Permit from Baker at NYPD. Use with Torres to add weapon slots. MISSABLE KEY ITEM
Mod Permit 2
Second permit from Baker at NYPD. MISSABLE KEY ITEM
Cm Vest 1
Chemical armor (DE 15+1, PE 16, CR 10+1, 2 slots). Uses Medicine when HP is low. NYPD locker room.
M16A1
Rifle (ATK 34+1, Range 110+2, 15+1 bullets, 1 slot). Given by Torres on Day 2.
M9
Pistol (ATK 17, Range 53+1, 8+1 bullets, 3 slots). Central Park, box near entrance (may be P8 instead).
Zoo Key
Central Park Key. KEY ITEM
Sp Vest 1
Spectra armor (DE 20+2, PE 14+1, CR 18+1, 2 slots). Central Park office.
Sv Vest 1
Survival armor (DE 18+1, PE 14+2, CR 19, 2 slots). Increases item capacity by 1. Central Park forest.
M203
Grenade launcher (ATK 25+2, Range 59+1, 5 bullets, 2 slots). Adds Heat effect. Central Park.
MP5K
Machine gun (ATK 35+1, Range 43, 23+1 bullets, 1 slot). NYPD Weapons Storage. Requires Storage Key (Day 3).
Bosses
BOSS Giant Worms
Large worm-like NMCs in Central Park. They emerge from the ground and attack with body slams. Use rifles or machine guns for rapid fire. Keep moving to avoid being surrounded.
BOSS Eve (Horse Ride)
Eve rides an immolated horse at the Delacorte Theater. She attacks with energy projectiles while moving. Time your attacks between her barrages. The fight ends when Aya is knocked unconscious — you don't need to defeat her here.
Day 3: Selection
Locations: Soho, NYPD, Chinatown | Date: December 26, 1997
Aya awakens in a Soho apartment with Daniel and Maeda. Maeda reveals Eve's origins — a scientist's wife's mitochondria took over her body. Maeda believes Eve is trying to give birth to an 'Ultimate Being.' The three visit Klamp again, then rush to the police station which has been attacked by Eve.
1
Wake up in the Soho apartment. Maeda explains the origins of Eve and the Ultimate Being theory.
2
Visit the Soho gun store for weapons and armor. Buy Trading Card 1 here.
3
Visit Dr. Klamp again. He tells Aya that the nuclei in her cells are fighting Eve's mitochondria. He asks questions then dismisses them.
4
Return to the NYPD precinct, which has been attacked by Eve. Save Ben and Baker from the mutated police dog Sheeva. Torres Owens is killed in the attack.
5
Explore Chinatown sewers for additional weapons and equipment. Find Trading Card 2.
6
Pick up the M92F pistol from Wayne at the NYPD.
Key Items
Trading Card 1
Normal Trading Card. Soho gun store. Give to Wayne for weapon mods. MISSABLE
Trading Card 2
Normal Trading Card. Chinatown. Give to Wayne for weapon mods. MISSABLE
M11
Machine gun (ATK 32+1, Range 42, 20+1 bullets, 2 slots). Soho gun store.
G19
Pistol (ATK 30+2, Range 57+1, 8+2 bullets, 3 slots). Soho gun store.
Cr Vest 1
Ceramics armor (DE 27+2, PE 24, CR 29+1, 2 slots). Soho.
Hamaya
Special good luck charm. Found in Soho/Chinatown area. KEY ITEM
Cm Vest 2
Chemical armor (DE 30+1, PE 33+2, CR 21+2, 2 slots). NYPD conference room.
M92F
Pistol (ATK 28+1, Range 50+1, 8+3 bullets, 3 slots). Given by Wayne on Day 3.
Storage Key
NYPD Weapons Storage Key. Allows access to MP5K. KEY ITEM
Locker Key
NYPD Locker Key. KEY ITEM
MP5K
Machine gun (ATK 35+1, Range 43, 23+1 bullets, 1 slot). NYPD Weapons Storage (use Storage Key).
SG550
Rifle (ATK 40, Range 108+2, 20+1 bullets, 2 slots). Dropped by Giant Dogman boss.
N Jacket
Normal armor (DE 34+1, PE 28+1, CR 19, 3 slots). NYPD 3rd floor.
M9-2
Pistol (ATK 38+1, Range 54+1, 10+1 bullets, 2 slots). Dropped by Sheeva (Kerberos) boss.
Bosses
BOSS Sheeva / Kerberos (Mutated Police Dog)
A mutated police dog with a barrier that makes it difficult to damage. Use offense boosters and items to break through its defenses. Physical attacks alone won't suffice — use Parasite Energy (Energy Shot or Liberate if available) and offensive items. It drops the M9-2 pistol. Torres is killed during this encounter.
Day 4: Conception
Location: St. Francis Hospital | Date: December 27, 1997
Aya and Maeda head to St. Francis Hospital, where Maeda believes Eve will try to obtain sperm for the Ultimate Being. The hospital is overrun with NMCs. Eve has already taken the sperm. Aya discovers her mother's and sister's medical records.
1
Enter St. Francis Hospital, overrun with NMCs. Try to save remaining staff and patients.
2
Explore the basement. Eve traps Aya by cutting off power to the elevator.
3
Restore elevator power using 3 fuses found in the basement.
4
Explore the upper floors. Discover Aya's mother's and sister's medical records.
5
Reach the rooftop. Eve telepathically kills fighter jet pilots. She has already taken the sperm and flees.
6
Defeat the Spiderwoman boss on the rooftop.
7
Aya jumps off the roof before it is struck by the crashing jets. Reunite with Daniel and Maeda.
Key Items
Mayoke
Helpful good luck charm. Found in the hospital. KEY ITEM
Fuse 1
Fuse for restoring elevator power. Hospital basement. KEY ITEM
Fuse 2
Fuse for restoring elevator power. Hospital basement. KEY ITEM
Fuse 3
Fuse for restoring elevator power. Hospital basement. KEY ITEM
M79
Grenade launcher (ATK 44+1, Range 65+2, 4+1 bullets, 3 slots). Adds Tranquilizer. Hospital basement.
Autopsy Key
St. Francis Hospital key. KEY ITEM
Blue Cardkey
Blue magnetic cardkey for hospital access. KEY ITEM
Green Cardkey
Green magnetic cardkey for hospital access. KEY ITEM
M10
Machine gun (ATK 37+1, Range 45, 22+2 bullets, 2 slots). Hospital basement (may be Micro UZ instead).
Super Tool
Moves equipped parameter or effect without destroying the source weapon. Hospital. VALUABLE
Sp Jacket
Spectra armor (DE 35, PE 29+1, CR 26, 2 slots). Hospital 1st floor.
G3A3
Rifle (ATK 43+1, Range 121+2, 18+1 bullets, 3 slots). Hospital 13th floor.
Elevator Key
Elevator key for hospital. KEY ITEM
B Vest 1
Bio armor (DE 29+1, PE 35, CR 20, 2 slots). Resist Poison. Hospital 1st floor.
Puzzle
Restore Elevator Power
Eve cuts off power to the hospital elevator, trapping Aya in the basement. Find all 3 fuses (Fuse 1, Fuse 2, Fuse 3) scattered in the basement area. Insert them into the fuse box to restore elevator power and continue exploring the upper floors.
Bosses
BOSS Spiderwoman (Rooftop)
A giant spider-like NMC on the hospital rooftop. It attacks with web projectiles that can immobilize Aya. Dodge the web attacks by moving constantly — strafe left and right. Use your best rifle or machine gun for sustained fire. The G3A3 (found on the 13th floor) is excellent here. Watch out for its lunging attack when you get too close.
Day 5: Evolution
Locations: Sewers, Warehouse, Museum | Date: December 28, 1997
Day 5 is the longest day, spanning three areas. Aya investigates the sewers, a warehouse, and the Museum of Natural History. She discovers Klamp engineered sperm for Eve, fights reanimated dinosaurs, and confronts a pregnant Eve at Liberty Island.
Part 1: Sewers
1
Enter the sewers following evidence of mutant slime in the water supply.
2
Use the control panel to pump orange slime away from the city's water reservoir, preventing contamination.
3
Navigate the sewer labyrinth, collecting the Pump Key, Warehouse Key, and Gate Key.
4
Find the Cr Protector armor in the sewer labyrinth (easy to miss).
Pump Key
Pumping station key. Sewers. KEY ITEM
Warehouse Key
Port storage key. Sewers. KEY ITEM
Gate Key
Subway gate key. Sewers. KEY ITEM
M203-2
Grenade launcher (ATK 48+1, Range 65, 6+1 bullets, 2 slots). Adds Heat effect. Warehouse.
M870
Shotgun (ATK 48+1, Range 60, 4+3 bullets, 6 slots). Burst: Spray Multiple Targets. Chinatown sewer.
Cr Protector
Ceramics armor (DE 39+2, PE 41+2, CR 25+1, 2 slots). Increases Max HP; AT recharges slower. Chinatown sewer labyrinth. MISSABLE
Pump Orange Slime from Water Supply
The orange mass of people from Central Park has entered the city water supply. Use the control panel in the sewer pumping station to pump the slime away, preventing it from infecting the city's water reservoir. This is a critical story puzzle.
Part 2: Warehouse
5
Enter the warehouse using the Warehouse Key from the sewers.
6
Collect armor and equipment, including the B Protector, Sp Protector, and Cm Protector.
B Protector
Bio armor (DE 32+1, PE 38, CR 22+1, 2 slots). Resist Stiffness. Subway.
M79-2
Grenade launcher (ATK 45+1, Range 68, 4+2 bullets, 4 slots). Adds Acid effect. Subway Station.
B Vest 1 (Warehouse)
May be found in warehouse area.
Sp Protector
Spectra armor (DE 38+1, PE 23, CR 26, 3 slots). Warehouse.
Cm Protector
Chemical armor (DE 36+1, PE 48, CR 31+2, 3 slots). Uses Medicine when HP is low. Warehouse.
Mayoke
Helpful good luck charm. Found during Day 5. KEY ITEM
Part 3: Museum of Natural History
7
Visit Dr. Klamp at the museum. Discover he has engineered special sperm for Eve to create the Ultimate Being. Aya tries to arrest him but he bursts into flames and dies after Daniel shoves him.
8
Fight reanimated dinosaurs in the museum exhibits.
9
Find a pregnant Eve in another part of the museum. The slime mass forms a giant monster that carries Eve away in its protective shield.
10
The military asks Aya to attack Eve from a helicopter (she's the only one who can approach without combusting). Attack from the chopper, then finish the fight on Liberty Island beside the wrecked Statue of Liberty.
MP5PDW
Machine gun (ATK 52+1, Range 46, 23+2 bullets, 2 slots). Museum 2nd floor.
Cr Vest 2
Ceramics armor (DE 45+1, PE 42+1, CR 31, 2 slots). Museum 2nd floor.
M203-4
Grenade launcher (ATK 57+1, Range 67, 7+1 bullets, 5 slots). Adds Frost effect. Museum 1st floor.
M500
Shotgun (ATK 57+2, Range 61+2, 5+2 bullets, 8 slots). Burst: Spray. Museum 4th floor.
N Suit
Normal armor (DE 43+1, PE 35+1, CR 22+1, 2 slots). Museum 1st floor.
Sv Protector
Survival armor (DE 38+1, PE 35+1, CR 30, 2 slots). Increases item capacity by 1. Museum 3rd floor.
B Jacket 1
Bio armor (DE 43+1, PE 48+1, CR 27+1, 3 slots). Resist Poison. Museum 4th floor, security room (right of control panels, secret elevator).
Bosses
BOSS Slime Monster
The orange slime mass from Central Park has become a giant monster. It surrounds Eve in a protective shield. You fight it from a helicopter first — use your best weapons to damage it. It has multiple attack patterns including sweeping slams and projectile slime.
BOSS Eve (Liberty Island)
The final confrontation with Eve beside the wrecked Statue of Liberty. Eve has multiple phases. Attack from the helicopter first, then fight her personally on the ground. She uses powerful energy attacks — use Barrier (if unlocked at Lv13) and Haste (Lv20) to survive. Use Energy Shot or Liberate for burst damage. Eve finally succumbs and dies.
Day 6: Liberation
Location: Naval Vessel | Date: December 29, 1997
Aya rests on a naval vessel. Maeda and Daniel are relieved she is safe. However, the Ultimate Being is born and attacks the surrounding ships. Aya must defeat it and escape before the ship explodes.
1
Rest on the naval vessel. Receive Maeda's Gun and DNA Bullets — the only weapons that can damage the Ultimate Being.
2
The Ultimate Being is born and attacks. Battle it across multiple forms as it evolves during the fight.
3
Set the vessel's boiler pressure dangerously high to destroy the ship with the Ultimate Being onboard.
4
Escape the ship before it explodes. Aya jumps off and the cruiser explodes, killing the Ultimate Being.
Key Items
Maeda's Gun
Pistol (ATK 1, Range 60, 15 bullets, 1 slot). Given by Maeda on Day 5/6. Cannot be removed from inventory. Required to damage the Ultimate Being. KEY ITEM
DNA Bullets
Maeda's special bullets for Maeda's Gun. Given near endgame. Required to damage the Ultimate Being. KEY ITEM
Bosses
BOSS Ultimate Being (4 Forms)
The Ultimate Being evolves through multiple forms during the fight, fusing with objects on the vessel. You MUST use Maeda's Gun with DNA Bullets — normal weapons cannot damage it. The being's mitochondria cause it to evolve at an alarming rate. Each form is stronger than the last. Use Liberate (if at Lv33) for massive burst damage. After weakening it, set the boiler pressure high and escape before the ship explodes. The cruiser explodes, killing the Ultimate Being.
TIP: After the credits roll, the EX Game (New Game+) unlocks, granting access to the Chrysler Building and the true final boss.
